The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer

Maud H.W. Starmans, Kenneth C. Chu, Syed Haider, Francis Nguyen, Renaud Seigneuric, Michael G. Magagnin, Marianne Koritzinsky, Arek Kasprzyk, Paul C. Boutros, Bradly G. Wouters, Philippe Lambin

Tumour hypoxia is associated with increased malignancy and poor prognosis. Recent data suggest that hypoxia gene-expression signatures have prognostic power. However, both tumour hypoxia and the biological adaptation to this stress are highly dynamic in space and time. Assessment of time-dependent gene-expression changes in response to hypoxia may thus provide additional biological insights an d help in prediction the impact of hypoxia on patient prognosis. Therefore, transcriptome profiling was performed for 3 cancer cell lines (DU145, HT29 and MCF7) after hypoxic exposure (0%) at 8 time-points (0, 1, 2, 4, 8, 12, 16 and 24 hours).

Download the datasets below.

Package icon DU145.zip71.4 MB
Package icon HT29.zip46.68 MB
Package icon MCF7.zip70.87 MB