EPTN consensus-based guideline for the tolerance dose per fraction of organs at risk in the brain

In collaboration with the European Particle Therapy Network (EPTN), a consensus table of tolerance doses for Organs at Risk in the brain was created. These values were all defined as a near maximum EQD₂ values. Using the linear quadratic formula the doses are recalculated depending on the number of fractions.

EQD₂ = equivalent dose in 2 Gy-fractions
D = the total dose
d = the dose per fraction
α/β = were derived from literature

Please note that this table does not include D_mean dose constraints, since these are comprised of the treatment plan’s mean dose and standard deviation, which are patient- and technique-dependent (for further reading and conversion [1,2]).

Please site as follows:

Eekers D, Lambrecht M, Nyström PDW, Swinnen A, Wesseling FWR, Roelofs E, Troost EG. EPTN consensus-based guideline for the tolerance dose per fraction of organs at risk in the brain, CancerData, 2018; doi:10.17195/candat.2018.01.1

References (more in the downloads)

Hoffmann AL, Nahum AE. Fractionation in normal tissues: the (α/β)eff concept can account for dose heterogeneity and volume effects. Phys Med Biol 2013;58:6897–914. doi:10.1088/0031-9155/58/19/6897.
Perkó Z, Bortfeld TR, Hong TS, Wolfgang J, Unkelbach J. Derivation of mean dose tolerances for new fractionation schemes and treatment modalities. Phys Med Biol 2017. doi:10.1088/1361-6560/aa9836.