A validated prediction model for overall survival from Stage III Non Small Cell Lung Cancer: towards survival prediction for individual patients.

Cary Oberije, Dirk De Ruysscher, Ruud Houben, Michel van de Heuvel, Wilma Uyterlinde, Joseph Deasy, Jose Belderbos, Anne-Marie C. Dingemans, Andreas Rimner, Shaun Din, Philippe Lambin

Purpose: Although homogeneous according to TNM staging system, stage III NSCLC patients form a heterogeneous group, which is reflected in the survival outcome. The increasing amount of information for an individual patient and the growing number of treatment options facilitate personalized treatment, but also complicate treatment decision making. Decision Support Systems (DSS), providing individualized prognostic information, can overcome this, but are currently lacking. A DSS for stage III NSCLC requires development and integration of multiple models.

Cardiac comorbidity is an independent risk factor for radiation-induced lung toxicity in lung cancer patients

Georgi Nalbantov, Bas Kietselaer, Katrien Vandecasteele, Cary Oberije, Maaike Berbee, Esther Troost, Anne-Marie Dingemans, Angela van Baardwijk, Kim Smits, André Dekker, Johan Bussink, Dirk De Ruysscher, Yolande Lievens, Philippe Lambin

Purpose: To test the hypothesis that cardiac comorbidity before the start of radiotherapy (RT) is associated with an increased risk of radiation-induced lung toxicity (RILT) in lung cancer patients.

Multivariate dyspnea nomogram