Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach

Hugo J. W. L. Aerts, Emmanuel Rios Velazquez, Ralph T. H. Leijenaar, Chintan Parmar, Patrick Grossmann, Sara Carvalho, Johan Bussink, René Monshouwer, Benjamin Haibe-Kains, Derek Rietveld, Frank Hoebers, Michelle M. Rietbergen, C. René Leemans, Andre Dekker, John Quackenbush, Robert J. Gillies, Philippe Lambin

Human cancers exhibit strong phenotypic differences that can be visualized noninvasively by medical imaging. Radiomics refers to the comprehensive quantification of tumour phenotypes by applying a large number of quantitative image features.