Human Papillomavirus

Externally validated HPV-based prognostic nomogram for oropharyngeal carcinoma patients yields more accurate predictions than TNM staging

Emmanuel Rios Velazquez, Frank Hoebers, Hugo J.W.L. Aerts, Michelle M. Rietbergen, Ruud H. Brakenhoff, C. René Leemans, Ernst-Jan Speel, Jos Straetmans, Bernd Kremer, Philippe Lambin

Purpose: Due to the established role of the human papillomavirus (HPV), the optimal treatment for oropharyngeal carcinoma is currently under debate. We evaluated the most important determinants of treatment outcome to develop a multifactorial predictive model that could provide individualized predictions of treatment outcome in oropharyngeal carcinoma patients.